This study aimed to investigate the effect of enamel caries lesion baseline severity on fluoride dose-response under pH cycling\nconditions. Early caries lesions were created in human enamel specimens at four different severities (8, 16, 24, and 36 h). Lesions\nwere allocated to treatment groups (0, 83, and 367 ppmfluoride as sodiumfluoride) based onVickers surface microhardness (VHN)\nand pHcycled for 5 d.The cyclingmodel comprised 3 Ã?â?? 1 min fluoride treatments sandwiched between 2 Ã?â?? 60 min demineralization\nchallenges with specimens stored in artificial saliva in between. VHN was measured again and changes versus lesion baseline were\ncalculated (Ã?â?VHN). Data were analyzed using two-way ANOVA (
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